The group is working on a range of research projects with a special focus on the development of new synthetic methods to access architecturally complex target molecules starting from accessible and cheap starting materials, and on the total synthesis of natural products and/or bioactive compounds (antitumoral, antibiotic, antifungal, compounds active on the CNS…).

We are active in several complementary areas, including:

1 - Coupling reactions induced by transition metals and metal complexes (Fe, Co, Pd, Ru, Rh)
2 - Cyclizations to construct heterocycles
3 - Rearrangements (cyclopropenes, prolinols, Wittig, Cope and Claisen rearrangements...)
4 - Enzymatic and organocatalytic methods including DNA-based asymmetric catalysis.

These methods have been applied to the synthesis of a number of natural products including leucascandrolide, mirabalin, hemicalide, amphidinol 3, lyngbouilloside, dictyostatin, melithiazole A, C, G and H, cystothiazole A and F, myxothiazole Z, oxobistramide, spirangien A, bitungolide F, pironetin…

For more information, please visit the group publication page or contact Professor Janine Cossy


Practical information

Director: Pr. Janine Cossy
Phone: +33 (0)1 40 79 44 29
Administrative assistant: Aroul Radja

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